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16:0(2R-OH) Ceramide
| 产品编号： | 4085921 |
| 规格： | N-(2′-(R)-hydroxypalmitoyl)-D-erythro-sphingosine, powder |
| CAS NO： | 34839-02-6 |
| 包装规格： | 5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
34839-02-6
16:0(2R-OH) Ceramide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C34H67NO4 |
| Molecular weight | 553.90 |
| NACRES | NA.25 |
| General description【一般描述】 | Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 16:0(2R-OH) Ceramide is a unique ceramide containing 16C long chain base fatty acid (palmitic acid)-with 2′-hydroxyl group in R configuration. |
| Biochem/physiol Actions【生化/生理作用】 | Hydroxy fatty acid (hFA)-sphingolipids are implicated in cell signaling. They may also help in regulation of cell differentiation and apoptosis. Synthetic 2′R-hydroxy-C16-ceramide exhibits high proapoptotic activity than proapoptotic 2′S-hydroxy-C16-ceramide. hFA-ceramides in epidermis support permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes neurological disorders including, leukodystrophy and spastic paraparesis in humans. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane. |
产品性质
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 860815P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCCCCCC)=O)CO |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (860815P-5mg) 5 mL Amber Glass Screw Cap Vial (860815P-25mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
