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AFMT racemate
产品别名
73804-76-9
AFMT racemate
Alpha-(FluoroMethyl)-D/L-Tyrosine
α-(Fluoromethyl)-D/L-tyrosine
(R/S)-2-Amino-3-fluoro-2-(4-hydroxybenzyl)propanoic acid
(R/S)-α-Fluoromethyltyrosine
D/L-AFMT
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H12FNO3 |
| Molecular weight | 213.21 |
| Biochem/physiol Actions【生化/生理作用】 | A racemic mixture of D- and L-AFMT. L-AFMT is reported to selectively inhibt against gut bacteria E. faecalis pyridoxal-5′-phosphate (PLP)-dependent tyrosine decarboxylase (TyrDC)-, but not aromatic amino acid decarboxylase (AADC)-, mediated L-dopa decarboxylation (IC50 = 4.7 μM/cell-free, 1.4 μM/in E. faecalis cultures; 20% human AADC inhibition at 650 μM) via covalent adduct formation with TyrDC co-factor PLP. When co-administered with L-dopa (10 mg/kg) and the AADC inhibitor carbidopa (30 mg/kg) to gnotobiotic mice colonized with E. faecalis, L-AFMT (25 mg/kg) significantly increases L-dopa peak serum concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=CC=C(C=C1)CC(N)(C(O)=O)CF |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
