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BDT001
产品别名
823837-22-5
BDT001
N-(5-Chloro-2-hydroxyphenyl)-3-(piperidin-1-ylsulfonyl) benzamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H19ClN2O4S |
| Molecular weight | 394.87 |
| Biochem/physiol Actions【生化/生理作用】 | BDT001 is a selective negative allosteric modulator of Flt-3 receptor tyrosine kinase. It showed minimal binding to 25 diverse RTKs and 49 intracellular kinases. In primary cultures of adult DRG neurons, BDT001 reversed the potentiation of capsaicin-induced TRPV1 activation by FL, with a maximal effect at 1 μM. In a mouse study BDT001 alleviated nerve injury-induced peripheral neuropathic pain but had no effect on nociception in non-injured animals. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=CC=C(C=C1NC(C2=CC=CC(S(N3CCCCC3)(=O)=O)=C2)=O)Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
