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Cilengitide trifluoroacetic acid salt
产品别名
188968-51-6
Cilengitide trifluoroacetic acid salt
Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl), 2,2,2-trifluoroacetate
EMD 121974
NSC 707544
c(RGDF(NMe)V)
2,2,2-trifluoroacetate
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H40N8O7 · xC2HF3O2 |
| Molecular weight | 588.66 (free base basis) |
| Application【应用】 | Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin αvβ5. |
| Biochem/physiol Actions【生化/生理作用】 | It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration. Cilengitide is a vascular targeting agent (VTA) that acts as an integrin antagonist. Cilengitide is a cyclized Arg-Gly-Glu(RGD)-containing pentapeptide that selectively blocks activation of the αvβ3 and αvβ5 integrins. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 20 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
