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Diquafosol tetrasodium
产品别名
211427-08-6
Diquafosol tetrasodium
Diuridine 5′-tetraphosphate, sodium salt
KPY 998
Diuridine 5′-tetraphosphate
Up4U tetrasodium
INS365
P ,P -Diuridine 5′-tetraphosphate tetrasodium salt
Uridine 5′-(pentahydrogen tetraphosphate), P′′′→5′-ester with uridine, sodium salt (1:4)
Up4U 4Na
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H22N4Na4O23P4 |
| Molecular weight | 878.23 |
| Biochem/physiol Actions【生化/生理作用】 | Diquafosol (Up4U, INS365) is a selective purinergic receptor P2Y2 agonist (EC50 = 100 nM/P2Y2, 400 nM/P2Y4, 20 μM/P2Y6, >100 μM/P2Y1 by calcium mobilization using respective 1321N P2Y subtype transfectants). In addition to its in vivo efficacy in anmial dry eye models, diquafosol is also shown to enhance mucociliary clearance in sheep and stimulate vaginal moisture in ovariectomized rabbits. P2Y2/P2Y4 purinoceptor agonist: EC50 = 0.10 μM at P2Y2, 0.4 μM at P2Y4 (20 μM at P2Y6) in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y1, P2Y2, P2Y4 and P2Y6 |
| Diagnostic Implications【诊断含义】 | In clinical development for the treatment of dry eye and chronic lung disease, such as cystic fibrosis |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >95% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -12.0 to -8.0°, c = 1.0 in H2O |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
