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EMI1
产品别名
35773-42-3
EMI1
3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one
3-(Benzoxazol-2-yl)-7-diethylamino-2H-benzopyran-2-one
3-(2-Benzoxazolyl)-7-(diethylamino)coumarin
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H18N2O3 |
| Molecular weight | 334.37 |
| MDL number | MFCD00489515 |
| Biochem/physiol Actions【生化/生理作用】 | EMI1 (ChemBridge 5213777) is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. Additionally, EMI1 potently depolymerized interphase microtubules, disrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
