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GeA-69
产品别名
2143475-98-1
GeA-69
N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H16N2O |
| Molecular weight | 300.35 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | off-white to brown |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
