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GSK1702934A
产品别名
924377-85-5
GSK1702934A
1,3-Dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
GSK-2934A
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H25N3O2S |
| Molecular weight | 395.52 |
| MDL number | MFCD08868156 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | GSK1702934A (GSK-2934A) is a direct activator of TRPC3 and TRPC6 ion channels with selectivity for TRPC3. In HEK293 kidney cells transduced with recombinant human TRPC3 or TRPC6, GSK1702934A activated current with an EC50 of ∼ 80 nM for TRPC3 vs. 440 nM for TRPC6. It does not activate TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations <10 μM. GSK1702934A has been used to study TRPC3 channels in the heart, exhibiting pro-arrhythmic, and inotropic actions in isolated Langendorff hearts from TRPC3-overexpressing mice. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1N(C2CCN(C(C3=CC(CCCCC4)=C4S3)=O)CC2)C5=CC=CC=C5N1 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
