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K-7174 dihydrochloride
产品别名
191089-60-8
K-7174 dihydrochloride
1,4-bis((E)-5-(3,4,5-Trimethoxyphenyl)pent-4-enyl)-1,4-diazepane dihydrochloride
K 7174 dihydrochloride
K7174 dihydrochloride
N,N?-bis-(E)-[5-(3,4,5-Trimethoxyphenyl)-4-pentenyl]homopiperazine dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C33H48N2O6 · 2HCl |
| Molecular weight | 641.67 |
| MDL number | MFCD28900671 |
| Biochem/physiol Actions【生化/生理作用】 | K-7174 is a homopiperazine with dual GATA and proteasome inhibitory activtiy. K-7174 selective inhibts GATA-mediated gene regulations in cultures (10-30 μM; VCAM-1 expression in HUVECs or Epo suppression in Hep3B cells) and in vivo (30 mg/kg in mice via i.p. against IL-1beta- or TNF-alpha-induced anemia). K-7174 exhibits anti-myeloma activity in vitro (10-25 μM) and in vivo (50 mg/kg/day p.o. in mice) by targeting the active pockets of β1, β2 and β5 subunits of proteasome along hydrophobic grooves in the direction of the β7, β1 and β4 subunits in a manner distinct from that of bortezomib. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | COC(C(OC)=C1)=C(C=C1/C=C/CCCN(CCC2)CCN2CCC/C=C/C3=CC(OC)=C(C(OC)=C3)OC)OC.[H]Cl.[H]Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
