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ML402
产品别名
298684-44-3
ML402
N-[2-(4-Chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide
N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H14ClNO2S |
| Molecular weight | 295.78 |
| MDL number | MFCD01990273 |
| Biochem/physiol Actions【生化/生理作用】 | ML402 is a selective activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) potassium channels. It was used to determine a cryptic selectivity filter binding site of the K2P2.1 (TREK-1) channel, designated the K2P modulator pocket. This binding pocket stabilizes an active "leak-mode" conformation, binding small-molecule activators that restrict the mobility of the selectivity filter and surrounding structure. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | ClC1=CC=C(OCCNC(C2=CC=CS2)=O)C(C)=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
