您的位置：首页 > 产品中心 > 730960-98-2， NSC 15520
NSC 15520
产品别名
730960-98-2
NSC 15520
15-Carboxy-13-isopropylatis-13-ene-17,18-dioic acid
NSC15520
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H34O6 |
| Molecular weight | 418.52 |
| MDL number | MFCD00057343 |
| Biochem/physiol Actions【生化/生理作用】 | NSC15520 is an inhibitor of the N-terminal protein interaction domain of Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, which is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. It has been shown to block the association of RPA to p53 and RAD9. In pluripotent stem cells, NSC 15520 increased targeted nucleotide substitutions in CRISPER reactions using Cas9n and Cpf1. It has been used along with a group of other small molecules to achieve a 2.8 to 7.2-fold increase in precision gene editing with Cas9. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
