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Odevixibat
产品别名
501692-44-0
Odevixibat
A 4250
AZD-8294
(2S)-2-[[(2R)-2-[[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]butanoic acid
A-4250
AZD8294
A4250
AZD 8294
(2S)-2-[(2R)-2-(2-{[3,3-Dibutyl-7-(methylsulfanyl)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1λ6,2,5-benzothiadiazepin-8-yl]oxy}acetamido)-2-(4-hydroxyphenyl)acetamido]butanoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C37H48N4O8S2 |
| Molecular weight | 740.93 |
| MDL number | MFCD32710220 |
| Biochem/physiol Actions【生化/生理作用】 | Odevixibat is an orally active, potent and selective ileal bile acid transporter (IBAT; ASBT; SLC10A2) inhibitor that improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis (0.01% w/w in diet). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=S1(C2=CC(OCC(N[C@H](C3=CC=C(C=C3)O)C(N[C@@H](CC)C(O)=O)=O)=O)=C(SC)C=C2N(C4=CC=CC=C4)CC(CCCC)(N1)CCCC)=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
