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PF-03491165
产品别名
950741-95-4
PF-03491165
PF03491165
PF-03491165-00-0006
(βR,dR)-5-Cyclopropyl-2-(4-fluorophenyl)-4-[[[(3-fluorophenyl)methyl]amino]carbonyl]-β,d-dihydroxy-1H-imidazole-1-heptanoic acid
(3R,5R)-7-(4-((3-Fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid
(3R,5R)-7-(5-Cyclopropyl-4-(3-fluorobenzylcarbamoyl)-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid
PF 03491165
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H29F2N3O5 |
| Molecular weight | 513.53 |
| Biochem/physiol Actions【生化/生理作用】 | PF-03491165 is a potent HMG-CoA reductase inhibitor (IC50 = 0.1 nM) with good hepatoselectivity (rat hepatocyte/myocyte cholesterol synthesis IC50 = 0.1 nM/444 nM). PF-03491165 exhibits superior plasma low density lipoprotein (LDL)-lowering efficacy than rosuvastatin and pravastatin in Guinea pigs in vivo (EC50 = 5.9, 13.5, 73.3 mg/kg, respectively via daily po) despite its low oral bioavailability in rats and dogs. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | FC1=CC=C(C=C1)C2=NC(C(NCC3=CC=CC(F)=C3)=O)=C(N2CC[C@H](C[C@H](CC(O)=O)O)O)C4CC4 |
