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PF-6274484
产品别名
1035638-91-5
PF-6274484
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H14ClFN4O2 |
| Molecular weight | 372.78 |
| MDL number | MFCD30182370 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823851 |
| Biochem/physiol Actions【生化/生理作用】 | PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | white to light brown |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | room temp |
| SMILES string | FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32 |
| InChI | 1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25) |
| InChI key | DTMQCGFVWWBONL-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
