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Reparixin
产品别名
266359-83-5
Reparixin
αR-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide
DF 1681Y
(R)-(-)-N-2-[(4-Isobutylphenyl)propionyl]methanesulfonamide
Repertaxin
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H21NO3S |
| Molecular weight | 283.39 |
| MDL number | MFCD18633292 |
| Biochem/physiol Actions【生化/生理作用】 | Reparixin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 (IL-8) chemokine receptors CXCR1 and CXCR2 with IC50 values of 1 nM for CXCR1 and 100 nM for CXCR2. It is believed to prevent receptor signaling by locking CXCR1/R2 in an inactive conformation. Reparixin has been studied to prevent ischaemia-reperfusion injury and inflammation and is clinical trials for triple negative breast cancer and to prevent injury occurring after pancreatic islet transplantation. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| optical activity【旋光性】 | [α]/D -80 to -90°, c = 1.0 in ethanol |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16) |
| InChI key | KQDRVXQXKZXMHP-UHFFFAOYSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
