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Ru265
产品别名
27056-01-5
Ru265
Ru2(μ-N)(NH3)8Cl2]Cl3
trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | Cl5H24N9Ru2 |
| Molecular weight | 529.66 |
| Biochem/physiol Actions【生化/生理作用】 | Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to dark beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
