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S3226
产品别名
S3226
S-3226
S 3226
3,3′-(4-Methyl-1,2-phenylene)bis[N-(aminoiminomethyl)-2-methyl-2-propenamide] dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H22N6O2 · 2HCl |
| Molecular weight | 415.32 |
| Biochem/physiol Actions【生化/生理作用】 | S3226 is also known as {3-[2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methyl-phenyl]-N-isopropylidene-2-methyl-acrylamide dihydro-chloride}. S3226 is used to explore the physiological and pathophysiological functions of sodium-hydrogen exchanger 3 (NHE3) in animal models. It is a bismethacryloyl guanidine derivative. S3226 is a potent and selective NHE3 (NHE-3) inhibitor (IC50 = 20 nM/human NHE3, 3.6 μM/human NHE1, 80 μM/rabbit NHE2) for studying NHE3 physiological as well as pathophysiological roles in kidney and gastrointestinal disorders in vitro and in animal models in vivo. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(N=C(N)N)C(C)=CC1=CC(C)=CC=C1C=C(C)C(NC(N)=N)=O.[H]Cl.[H]Cl |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
