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Santacruzamate A
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4086374 | 5 MG | 897 | |||
| 4086374 | 25 MG | 3150 |
产品别名
1477949-42-0
Santacruzamate A
CAY 10683
CAY-10683
N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]carbamic acid ethyl ester
CAY10683
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H22N2O3 |
| Molecular weight | 278.35 |
| MDL number | MFCD28348356 |
| Biochem/physiol Actions【生化/生理作用】 | Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = > 1 μM and 433.5 nM, respectively). CAY10683 readily enhances cellular acetylated HDAC2 levels upon LPS-stimulation and only modestly inhibits HuT-78 cutaneous T-cell lymphoma and HCT-116 colon carcinoma cells growth (GI50 = 1.4 and 29.4 uM, respectively). It alleviates acute liver failure (ALF) in rats (i.p.) and rescues cognitive deficits in APPswe/PS1dE9 mice (p.o.). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
