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SEW84
产品别名
259089-67-3
SEW84
1-(4-Fluorophenyl)-1H-pyrrole-2-carboxylic acid 2-[thioxo[[3-(trifluoromethylphenyl]-amino]methyl]hydrazide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H14F4N4OS |
| Molecular weight | 422.40 |
| MDL number | MFCD01764773 |
| Biochem/physiol Actions【生化/生理作用】 | SEW84 is a potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity without inhibition of basal Hsp90 ATPase. It binds to the C-terminal domain of Aha1 and weakens the Hsp90-Aha1 interaction. SEW84 inhibits Aha1-dependent Hsp90 chaperoning activities including refolding of denatured firefly luciferase (in vitro) and in vivo transcriptional activity of the glucocorticoid receptor and AR androgen receptor in prostate cancer cell-based models. SEW84 preferentially clears Alzheimer disease related phosphorylated aggregation-prone Tau in primary rat cortical neurons. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
