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Tasisulam
产品别名
519055-62-0
Tasisulam
LY 573636
LY-573636
N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide
N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide
LY573636
N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H6BrCl2NO3S2 |
| Molecular weight | 415.11 |
| MDL number | MFCD11973637 |
| Biochem/physiol Actions【生化/生理作用】 | Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) that bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC50 = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
