您的位置：首页 > 产品中心 > 1451750-73-4， TETi76 diethyl ester
TETi76 diethyl ester
产品别名
1451750-73-4
TETi76 diethyl ester
AD145
Diethyl 2-hydroxy-4-methylenepentanedioate
TETi76 ester
2-Hydroxy-4-methylene-pentanedioic acid, 1,5-diethyl ester
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H16O5 |
| Molecular weight | 216.23 |
| Biochem/physiol Actions【生化/生理作用】 | TETi76 diethyl ester is a cell-permeant diester form of the α-KG-competitive and hightly selective TET1/2/3 dioxygenase inhibitor TETi76 acid (TET2 cat. domain Kd = 0.3 μM; no potency against 16 other αKG/Fe2+-dependent enzymes, including closely related RNA dioxygenase FTO). TETi76 ester downregulates cellular 5-hydroxymethylcytosine (5hmC) levels (IC50 = 20-37 μM; K562, MEG01, SIGM5, OCI-AML5, MOLM13), exerts preferential cytotoxicity in TET-deficient cultures (TET2/3-knockout K562 LD50 ~10 μM vs wt K562 LD50 ~40 μM) and significantly reduces TET2-deficient SIGM5 tumor burden in mice in vivo (50 mg/kg p.o.). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (GC) |
| form【形式】 | oil |
| color【颜色】 | colorless to yellow |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
