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TMI-1
产品别名
287403-39-8
TMI-1
WAY-171318
TMI 1
4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H22N2O5S2 |
| Molecular weight | 398.50 |
| PubChem Substance ID【PubChem化学物质编号】 | 329823847 |
| Biochem/physiol Actions【生化/生理作用】 | TMI-1 (WAY-171318) is potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) also known as the tumor necrosis factor-α (TNF-α) converting enzyme (TACE), and matrix metalloprotease (MMP). TMI-1 potently inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines. |
| Other Notes【其他说明】 | This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer. |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 25 mg/mL, clear |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | room temp |
| SMILES string | O=S(N1[C@@H](C(NO)=O)C(C)(C)SCC1)(C2=CC=C(OCC#CC)C=C2)=O |
| InChI | 1S/C17H22N2O5S2/c1-4-5-11-24-13-6-8-14(9-7-13)26(22,23)19-10-12-25-17(2,3)15(19)16(20)18-21/h6-9,15,21H,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1 |
| InChI key | CVZIHNYAZLXRRS-HNNXBMFYSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
