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TP-008
产品别名
1976038-41-1
TP-008
2-(1-(2-(5-Chloro-2-fluorophenyl)-5-methylpyridin-4-yl)-2-oxo-1H-imidazo[4,5-c]pyridin-3(2H)-yl)acetamide
1-[2-(5-Chloro-2-fluorophenyl)-5-methyl-4-pyridinyl]-1,2-dihydro-2-oxo-3H -imidazo[4,5-c ]pyridine-3-acetamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H15ClFN5O2 |
| Molecular weight | 411.82 |
| Biochem/physiol Actions【生化/生理作用】 | SGC Frankfurt Pharma donated probe. TP-008 is a cell penetrant, potent and selective ALK4/5 ((activin-like kinase 4/5) dual inhibitor that potently inhibits SMAD2/3 phosphorylation in C2C12 cells. TP-008 exhibits significant cardiac toxicity in mice. It is compound 18 in BMCL 2016 paper. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
