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UCSF924
产品别名
1434515-70-4
UCSF924
6-Methyl-2-((3-phenoxypropylamino)methyl)quinolin-4(1H)-one
ZINC000091726127
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H22N2O2 |
| Molecular weight | 322.40 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | UCSF924 (Compound 9-6-24; ZINC000091726127) is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC (Comound 9-6-16; ZINC000091707446) is the recommended negative control compound with a 1/2500-fold reduced D4 affinity. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC1=CC=C(NC(CNCCCOC2=CC=CC=C2)=CC3=O)C3=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
