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UNC3866 trifluoroacetate salt
产品别名
UNC3866 trifluoroacetate salt
N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C43H66N6O8 |
| Molecular weight | 795.02 |
| Biochem/physiol Actions【生化/生理作用】 | UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression. Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1 |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | lyophilized powder (white) |
| color【颜色】 | white to off-white |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
