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(Z)-Endoxifen
产品别名
(Z)-Endoxifen
N-Desmethyl-4-hydroxytamoxifen
Metabolite BX
4-Hydroxy-N-desmethyl-tamoxifen
Endoxifen
Z-Endoxifen
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H27NO2 |
| Molecular weight | 373.49 |
| MDL number | MFCD09840374 |
| Application【应用】 | (Z)-Endoxifen has been used to demonstrate the lack of contribution of subventricular zone and leptomeningeal cells in a study determining the generation of neuroblasts from astrocytes. |
| Biochem/physiol Actions【生化/生理作用】 | (Z)-Endoxifen (endoxifen) is an active tamoxifen metabolite generated via actions of cytochrome P450 (CYP) enzymes CYP3A4/5 and CYP2D6. Endoxifen is more potent than tamoxifen as a selective estrogen receptor modulator (SERM) both in vitro and in vivo with good pharmacokinetics and oral availability (∼80% MCF-7 tumor growth inhibition with 4-8 mg/kg/day endoxifen or 20 mg/kg/day tamoxifen in mice via p.o.). Endoxifen also exhibits 4-fold higher PKC inhibitory potency than tamoxifen and can overcome tamoxifen resistance due to cytochrome CYP2D6 polymorphism. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Pictograms【象形图】 | GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 - P391 - P501 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
