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APC366 trifluoroacetate
产品别名
158921-85-8
APC366 trifluoroacetate
APC 366 trifluoroacetate
N2-[(1-Hydroxy-2-naphthalenyl)carbonyl]-L-arginyl-L-prolinamide trifluoroacetate
N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H28N6O4 · xC2HF3O2 |
| Molecular weight | 440.50 (free base basis) |
| Biochem/physiol Actions【生化/生理作用】 | APC366 is a selective inhibitor of mast cell tryptase, which is involved with allergenic response. It thereby also inhibits protease-activated receptor PAR2, a G-protein-coupled receptor that is activated by mast cell tryptase. Tryptase has been proposed to be involved in fibrosis, joint inflammation and also in promoting breast cancer angiogenesis, all of which APC366 inhibited. |
产品性质
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | lyophilized powder |
| color【颜色】 | white to off-white |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | FC(F)(C(O)=O)F.NC(NCCC[C@@H](C(N1CCC[C@H]1C(N)=O)=O)NC(C2=C(O)C3=CC=CC=C3C=C2)=O)=N |
