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Atopaxar hydrobromide
产品别名
751475-53-3
Atopaxar hydrobromide
E-5555
ER 172594-06
ER-172594-00 hydrobromide
2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone, monohydrobromide
E 5555
1-(3-tert-Butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-2H-isoindol-2-yl)ethanone hydrobromide
E5555
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H38FN3O5 · xHBr |
| Molecular weight | 527.63 (free base basis) |
| Biochem/physiol Actions【生化/生理作用】 | Atopaxar (E5555) is an orally active, potent and selective thrombin receptor (protease-activated receptor; PAR1) antagonist (IC50 = 19 nM/E5555 vs. 490 nM/TRAP against 10 nM haTRAP for PAR-1 binding on human platelet membranes) that inhibits platelet aggregation induced by thrombin or TRAP T (human platelet IC50 = 64/31 nM against 1 u/mL Thrombin/5 μM TRAP; guinea pig IC50 = 13/97 nM against 2 u/mL Thrombin/20 μM TRAP), but not ADP, U46619, collagen, PAR-4ap or PAF. Atopaxar exhibits antithrombotic efficacy in guinea pigs and rats in vivo (10, 30, 100 mg/kg p.o.). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(CN1C(C2=C(C(OCC)=C(C=C2C1)OCC)F)=N)C(C=C3N4CCOCC4)=CC(C(C)(C)C)=C3OC.[xHBr] |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
