您的位置：首页 > 产品中心 > 566203-88-1， AZD-2098
AZD-2098
产品别名
566203-88-1
AZD-2098
2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
AZD 2098
2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
AZD2098
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H9Cl2N3O3S |
| Molecular weight | 334.18 |
| MDL number | MFCD31382158 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ∼120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge). |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
