您的位置：首页 > 产品中心 > 2143467-62-1， BPK-29
BPK-29
产品别名
2143467-62-1
BPK-29
2-Chloro-N-[hexahydro-1-[4-(4-morpholinyl)benzoyl]-1H-azepin-4-yl]-N-(phenylmethyl)-acetamide
N-Benzyl-2-chloro-N-[1-(4-morpholin-4-yl-benzoyl)-azepan-4-yl]-acetamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H32ClN3O3 |
| Molecular weight | 470.00 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | BPK-29 is a small molecule inhibitor that blocks the nuclear factor erythroid 2–related factor 2 (NRF2) pathway. It targets the cysteine 274 residue in the nuclear receptor subfamily 0 group B member 1 (NR0B1) and disrupts protein-protein interactions in non-small-cell lung cancer (NSCLC) cell proteomes. BPK-29 is a potent and selective NR0B1 ligand that covalently binds to NR0B1 Cys 274. BPK-29 inhibits the NR0B1-SNW1 interaction. It inhibits the anchorage-independent growth of KEAP1-mutant cancer cells. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(CCl)N(C1CCN(C(C2=CC=C(N3CCOCC3)C=C2)=O)CCC1)CC4=CC=CC=C4 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
