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Bragsin2
产品别名
342795-08-8
Bragsin2
6-Methoxy-5-nitro-2-(trifluoromethyl)-4H-1-benzopyran-4-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H6F3NO5 |
| Molecular weight | 289.16 |
| MDL number | MFCD02626267 |
| Biochem/physiol Actions【生化/生理作用】 | Bragsin2 is a hydration resistant cell penetrant, potent and selective noncompetitive inhibitor of ArfGEF BRAG2 (Afr guanine nucleotide exchange factor BRAG2) that inhibits Arf GTPase activation in vitro and in cells. It binds to pleckstrin homology (PH) domain of BRAG2 and misposition BRAG2 on the membrane. Bragsin2 disrupt the function of the yeast ArfGEF Sec7p. Bragsin2 suppresses tumorsphere formation of some breast cancer stem cell lines including SUM149 and S68. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
