您的位置：首页 > 产品中心 > 329198-87-0， C-178
C-178
产品别名
329198-87-0
C-178
C 178
C178
N-(Dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide
N-Dibenzofuran-3-yl-5-nitrofuran-2-carboxamide
N-3-Dibenzofuranyl-5-nitro-2-furancarboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H10N2O5 |
| Molecular weight | 322.27 |
| MDL number | MFCD01146392 |
| Biochem/physiol Actions【生化/生理作用】 | C-178 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-178 inhibits mSTING-mediated IFNβ reporter activity (IC50 <500 nM) without affecting RIG-I, and blocks (0.5 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | faint yellow to dark brown |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC(OC3=C4C=CC=C3)=C4C=C2 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
