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CA3
产品别名
300802-28-2
CA3
2,7-bis(1-Piperidinylsulfonyl)-9H-fluoren-9-one oxime
CIL56
1,1′-[[9-(Hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C23H27N3O5S2 |
| Molecular weight | 489.61 |
| MDL number | MFCD00323348 |
| Biochem/physiol Actions【生化/生理作用】 | CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity. |
产品性质
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
