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Cathepsin K Active from mouse
| 产品编号： | 4086655 |
| 规格： | recombinant, expressed in E. coli, ≥90% (SDS-PAGE) |
| 包装规格： | 5 μG，50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Cathepsin K Active from mouse
CTSO3
CTSO
CTSK
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity. |
| Biochem/physiol Actions【生化/生理作用】 | Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death. |
| Physical form【外形】 | 0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol. |
产品性质
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | liquid |
| mol wt【分子量】 | 23.4 kDa (115-329 aa) |
| packaging【包装】 | pkg of 5 μg pkg of 50 μg |
| concentration【浓度】 | 0.5 mg/mL |
| UniProt accession no.【UniProt登记号】 | P55097 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | mouse ... CTSK(13038) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
