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CBLC000 trifluoroacetate
产品别名
324780-02-1
CBLC000 trifluoroacetate
N,N-Diethyl-3,6-dinitro-9H-carbazole-9-ethanamine trifluoroacetate
9H-Carbazole-9-ethanamine, N,N-diethyl-3,6-dinitro- trifluoroacetate
Curaxin CBLC000 trifluoroacetate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H20N4O4 · C2HF3O2 |
| Molecular weight | 470.40 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | CBLC000 is a potent inhibitor of FACT (facilitates chromatin transcription) complex that activates p53 and suppresses NF-kB without genotoxicity. CBLC000 induces chromatin trapping of FACT both in vitro and in vivo. CBLC000 exhibits brad anticancer activity. CBLC000 analog clinical candidate CBL0137 decreases self-renewal of GBM stem cells (GSC). |
产品性质
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCN(CC)CCN1C2=C(C=C([N+]([O-])=O)C=C2)C3=C1C=CC([N+]([O-])=O)=C3.FC(F)(C(O)=O)F |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H315 - H413 |
| Precautionary Statements | P273 - P301 + P312 + P330 - P302 + P352 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Chronic 4 - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
