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CGP 48664 dihydrochloride
产品别名
138794-73-7
CGP 48664 dihydrochloride
4-Amidino-1-indanone-2′-amidinohydrazone dihydrochloride
4-Amidinoindan-1-one-2?-amidinohydrazone dihydrochloride
CGP48664 dihydrochloride
(E)-2-[4-(Aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide dihydrochloride
SAM486A dihydrochloride
Sardomozide dihydrochlorid
CGP 48664A dihydrochloride
CMA 48664 dihydrochloride
Sardomozide dihydrochloride
(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H14N6 · 2HCl |
| Molecular weight | 303.19 |
| MDL number | MFCD00910325 |
| Biochem/physiol Actions【生化/生理作用】 | CGP 48664 (SAM486A; Sardomozide) is a polyamine (PA) biosynthesis inhibitor (73% and 97% downregulation of murine leukemia L1210 cellular spermidine and spermine, respectively, by 0.5 μM Sardomozide in 4 days) that targets the rate-limiting enzyme S-adenosylmethionine decarboxylase (AdoMetDC, SAMDC, AMD1) in a potent (IC50 = 5 nM against rat AMD1) and selective manner with little or no inhibitory efficacy toward diamine oxidase or ornithine decarboxylase (IC50 = 18 μM and >50 μM against rat DAO and ODC, respectively). CGP 48664 effectively inhibits the proliferation of murine (GI50 = 0.5 μM against L1210 in 4 days) and human cancer cell lines in cultures (GI50 from 0.26 to 0.6 μM in 5 days; GI50 = 0.8 μM against human melanoma SK MEL-24 in 10 days) and suppresses the growth of murine and human tumor xenografts in mice in vivo (ED50 ≤0.5 mg/kg i.p.). CGP 48664 (Sardomozide) potently inhibits growth of PFA ependymoma cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | NC(C1=CC=CC2=C1CC/C2=N\NC(N)=N)=N.Cl.Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
