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Clascoterone
产品别名
19608-29-8
Clascoterone
21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
CB-03-01
Cortexolone 17α-propionate
C17P
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H34O5 |
| Molecular weight | 402.52 |
| MDL number | MFCD18384978 |
| Biochem/physiol Actions【生化/生理作用】 | Clascoterone is a high-affinity androgen receptor (AR) antagonist (antiandrogen) that antagonizes testosterone-stimulated transcription activity (in reporter cells) as well as DHT-induced production of lipids and inflammatory cytokines (in human sebocytes) in cultures. When applied topically, clascoterone is as active as cyproterone acetate, and 2-, 3-, and 4-times, respectively, more active than finasteride, flutamide, and progesterone in vivo (local antiandrogenic activity in hamster′s flank organ; 100-400 μg/50 μL acetone/animal). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCC(O[C@]1(C(CO)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O |
