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CU-CPT9a
产品别名
2165340-32-7
CU-CPT9a
2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol
Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H15NO2 |
| Molecular weight | 265.31 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC1=CC(C2=CC=NC3=CC(OC)=CC=C23)=CC=C1O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
