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ICCB-19 Hydrochloride
产品别名
1803605-68-6
ICCB-19 Hydrochloride
N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H21N3OS · HCl |
| Molecular weight | 291.84 |
| MDL number | MFCD28145281 |
| Biochem/physiol Actions【生化/生理作用】 | ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(NC1CCCCCC1)CSC2=NCCN2.Cl |
