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IMB5046
产品别名
1001571-08-9
IMB5046
2-(4-Morpholinyl)-5-nitro-benzoic acid [4-(methylthio)phenyl]methyl ester
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H20N2O5S |
| Molecular weight | 388.44 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. IMB5046 was cytotoxic with an IC50 range of 37 to 426 nM against multiple tumor cell lines, including some that were resistant to colchicine, vincristine and paclitaxel. IMB5046 was also active against human lung tumor xenografts. IMB5046 was found to bind to tubulin at the colchicine site, but with a different binding mode. IMB5046 inhibited tubulin polymerization, and induced G2/M arrest. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C1=C(N2CCOCC2)C=CC([N+]([O-])=O)=C1)OCC3=CC=C(SC)C=C3 |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
