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KEA1-97
产品别名
2138882-71-8
KEA1-97
4,6-Dichloro-N-(4′-fluoro-[1,1′-biphenyl]-4-yl)-1,3,5-triazin-2-amine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H9Cl2FN4 |
| Molecular weight | 335.16 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | FC1=CC=C(C2=CC=C(NC3=NC(Cl)=NC(Cl)=N3)C=C2)C=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
