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L67
产品别名
325970-71-6
L67
N-(3,5-Dibromo-4-methylphenyl)-glycine 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
LigI/III inhibitor L67
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H14Br2N4O4 |
| Molecular weight | 486.11 |
| MDL number | MFCD00363966 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826071 |
| Biochem/physiol Actions【生化/生理作用】 | L67 is a potent and specific inhibitor of DNA ligase IIIα (LigIIIα) that preferentially targets mitochondrial LigIIIα resulting in mitochondrial dysfunction. L67 preferentially targets cancer cell mitochondria resulting in enhanced ROS production and caspase 1-dependent apoptosis. L67 in combination with PARP inhibitors decreases survival rate of therapy resistant breast cancer and leukemia cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 10 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)CNC2=CC(Br)=C(C)C(Br)=C2 |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Hazard Statements | H413 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 4 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
