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LLY-284
产品别名
LLY-284
(2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol
LLY284
(S)-5′-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5′-phenyl(ribofuranosyl)]-7-deazapurine
LLY 284
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H18N4O4 |
| Molecular weight | 342.35 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website. LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc |
| Features and Benefits【特点和优势】 | LLY-284 is a negative control for LLY-283, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
