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MG149
产品别名
1243583-85-8
MG149
MG 149
2-(4-Heptylphenethyl)-6-hydroxybenzoic acid
2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H28O3 |
| Molecular weight | 340.46 |
| MDL number | MFCD22123243 |
| Biochem/physiol Actions【生化/生理作用】 | MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
