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O4I3
产品别名
88965-00-8
O4I3
6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
2-(4-Methylphenyl)-6-methylimidazo[1,2-a]pyridine
OCT4-inducing compound 3
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H14N2 |
| Molecular weight | 222.29 |
| MDL number | MFCD00444739 |
| Biochem/physiol Actions【生化/生理作用】 | O4I3 is a highly potent and KDM5A (JARID1A) subtype-selective H3K4 demethylase KDM5 inhibitor (KDM5A IC50 = 0.15 nM vs KDM5B/C/D IC50 = 125.2/9.76/4.7 nM, KDM4 IC50 = 249 nM, LSD1 IC50 >100 μM) that effectively induces OCT4 expresson and improves OSKM-induced pluripotent stem cell (iPSC) reprogramming efficiency of human primary fibroblasts (50 nM) by preventing KDM5A from interfering with H3K4Me3 enrichment at the OCT4 promoter. O4I3 promotes hPSC homeostasis and represses cellular differentiation, increasing hPSCs viability up to 4-fold at a low 10 nM concentration when compared with Rock inhibitor Y-27632 treatment at 10 μM. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1=CC=C(C2=CN3C=C(C=CC3=N2)C)C=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
