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PF-06869206
产品别名
PF-06869206
PF06869206
PF 06869206
(S)-3-Chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H14ClF3N4O2 |
| Molecular weight | 374.75 |
| NACRES | NA.77 |
| Application【应用】 | PF-06869206 has been used to selectively inhibit the activity of sodium-phosphate cotransporter 2a (NaPi2a). |
| Biochem/physiol Actions【生化/生理作用】 | PF-06869206 is a selective inhibitor against sodium-phosphate cotransporter 2A (NaPi-2a, NaPi-Iia, Na+/Pi cotransporter 2A, Na+-dependent phosphate cotransporter 2A). PF-06869206 may be used to treat patients with mineral and hormonal derangements linked with increased cardiovascular risk in chronic kidney disease. This drug might also improve urinary phosphate excretion. PF-06869206 has an ability to decrease phosphate uptake in human embryonic kidney (HEK) cells transfected with mouse or rat renal sodium-dependent phosphate transporter genes (Npt2a). |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc Pfizer is a registered trademark of Pfizer, Inc. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Pfizer® |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| originator【创始人】 | Pfizer |
| storage temp.【储存温度】 | room temp |
| SMILES string | ClC1=C(C)NC2=C1N=C(C(F)(F)F)C(C#N)=C2N3C[C@@H](CO)OCC3 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
