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PSEM308 hydrochloride
产品别名
PSEM308 hydrochloride
5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3′,2′:3,4]diazepino[6,7,1-hi]indole hydrochloride
5-Methyl-3,4,14-triazapentacyclo[12.2.2.14,7.02,13.011,19]nonadeca-2,7(19),8,10-tetraene hydrochloride
PSEM 308 hydrochloride
Pharmacologically selective effector molecule 308, hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H21N3 · HCl |
| Molecular weight | 303.83 |
| MDL number | MFCD31689250 |
| Biochem/physiol Actions【生化/生理作用】 | SEM308 is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F or L141F/Y115F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML141F-GlyR & PSAML141F/Y115F-GlyR) and 5-HT3 (PSAML141F/Y115F-5-HT3). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1CC2=CC=CC3=C2N1N=C(C4CCN5CC4)C5C3.Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
