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sAJM589
产品别名
2089-82-9
sAJM589
5-Hydroxybenzo[a]phenazine
Benzo[a]phenazin-5-ol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H10N2O |
| Molecular weight | 246.26 |
| MDL number | MFCD00437759 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | yellow to orange |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
