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SHetA2
产品别名
361483-66-1
SHetA2
NSC 726189
N-(3,4-Dihydro-2,2,4,4-tetramethyl-2H-1-benzothiopyran-6-yl)-N′-(4-nitrophenyl)thiourea
NSC726189
NSC-726189
Sulfur Heteroarotinoid A2
1-(4-Nitrophenyl)-3-(2,2,4,4-tetramethylthiochroman-6-yl)thiourea
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H23N3O2S2 |
| Molecular weight | 401.55 |
| Biochem/physiol Actions【生化/生理作用】 | SHetA2 is an orally available chemopreventive fexible heteroarotinoid (Flex-Het) that inhibits cancer growth in cultures (OVCAR-3/SK-OV-3/Caov-3 GI50 = 3.9/4.1/7.0 μM) and in vivo (60-100 mg/kg SiHa xenograft mice) via apoptosis induction independent of retinoic acid receptor (RAR). SHetA2 is reported to bind heatshock proteins HSPA5 (GRP78, BiP), HSPA8 (HSC70, HSP73, HSPA10), HSPA9 (GRP75), resulting in cyclin D1 degradation. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | S=C(NC1=CC=C2SC(C)(CC(C)(C)C2=C1)C)NC(C=C3)=CC=C3[N+]([O-])=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
