您的位置：首页 > 产品中心 > 133406-29-8， ST034307
ST034307
产品别名
133406-29-8
ST034307
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
6-Chloro-2-(trichloromethyl)chromen-4-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H4Cl4O2 |
| Molecular weight | 297.95 |
| MDL number | MFCD00760793 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | faint green to dark gray |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
